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Search Results for " protein kinases "

ターゲット

CaMK Autophagy

149

阻害剤

天然化合物

358

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
T14860	CaMKII-IN-1		CaMK , Autophagy
	CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor (IC50: 63 nM). It has significantly high selectivity against CaMKIV, p38a, MLCK, Akt1, and PKC.		CaMK , Autophagy
T3546	STO-609	STO 609	CaMK , AMPK , Autophagy
	STO-609 is a specific and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα/KKβ (Ki: 80/15 ng/mL).		CaMK , AMPK , Autophagy
T2697	KN-93		CaMK , Autophagy
	KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.		CaMK , Autophagy
TQ0137	A-484954	A 484954	CaMK , Parasite , Autophagy
	A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.		CaMK , Parasite , Autophagy
TP2310	Autocamtide-2-related inhibitory peptide		CaMK , Autophagy
	Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.		CaMK , Autophagy
T6605	NH125		CaMK , Virus Protease , PKA , Antibacterial , PKC , Autophagy , Antifungal
	NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
T14069	A-3 hydrochloride		CaMK , Casein Kinase , PKA , PKC
	A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectiv...		CaMK , Casein Kinase , PKA , PKC
T2694	KN-62		CaMK , P2X Receptor , Autophagy
	KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.		CaMK , P2X Receptor , Autophagy
T21588	Olomoucine		ERK , CDK
	Olomoucine is an ATP competitive inhibitor of Cdk2/cyclin A, Cdc2/CyclinB, CDK2/CyclinE, CDK5/p35, and ERK1/p44 MAP kinase with IC50s of 7, 7, 7, 3 and 25 µM, respectively. Olomoucine regulates cell cycle and exhibits an...		ERK , CDK
T9305	Necroptosis-IN-1		RIP kinase
	Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.		RIP kinase
T15437	GSK3145095		RIP kinase
	GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.		RIP kinase
T7151	GSK2982772		RIP kinase
	GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.		RIP kinase
T6815	HS-1371		RIP kinase
	HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.		RIP kinase
T3537	GSK583		RIP kinase
	GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).		RIP kinase
T7795	RIPA-56		RIP kinase
	RIPA-56 is an inhibitor of RIP1		RIP kinase
T8574	SPHINX		Others
	SPHINX is a new generation inhibitor of SPRK1		Others
T10667	Calmidazolium chloride	R 24571	CaMK , Autophagy
			CaMK , Autophagy
T8389	Trifluoperazine	trifluoroperazine	CaMK , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , P-gp , Autophagy
	Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.
T9702	Eclitasertib		RIP kinase
	Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).		RIP kinase
T5054	GSK963	GSK963 (Racemate)	RIP kinase
	GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).		RIP kinase
T6852	GSK481	GSK'481	RIP kinase
	GSK481 (GSK'481) is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.		RIP kinase
T1954	SRPIN340	SRPK inhibitor	Virus Protease , Serine/threonin kinase
	SRPIN340 (SRPK inhibitor), a serine/arginine-rich protein kinase (SRPK)-specific inhibitor, is potent for SRPK1 (IC50 = 0.89 uM).		Virus Protease , Serine/threonin kinase
T7397	GSK547	GSK'547	RIP kinase
	GSK547 (GSK'547) is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.		RIP kinase
T11501	GSK840	GSK'840	RIP kinase
			RIP kinase
T1843	XMD8-92		ERK , BMI-1 , Epigenetic Reader Domain
	XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).		ERK , BMI-1 , Epigenetic Reader Domain
T21980	PD 198306		MEK
	PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of active ERK1.		MEK
T12731	RIPK1-IN-7		RIP kinase
	RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.		RIP kinase
T21295	BIX02189	BIX 02189	ERK , MEK
	BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).		ERK , MEK
T11492	GSK2983559 free acid		Others , RIP kinase
	GSK2983559 free acid is a specific and orally bioavailable inhibitor of receptor-interacting protein 2 (RIP2) kinase. It has excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inf...		Others , RIP kinase
T4496	LM22B-10	LM22B10	ERK , Trk receptor , Akt
	LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.		ERK , Trk receptor , Akt
T1222	Trifluoperazine dihydrochloride	Trifluoperazine 2HCl,SKF5019,Urinox	CaMK , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , P-gp , Autophagy
	Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
T12493	PK68		Others , RIP kinase
	PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90 nM). PK68 can be used for research on the treatment of inflammatory disorders and cancer metastasis.		Others , RIP kinase
T4185	Lavendustin C	HDBA,NSC 666251	CaMK , EGFR , Tyrosinase , Src
	lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.		CaMK , EGFR , Tyrosinase , Src
T7506	Yoda 1		Piezo Channel
	Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells, respectively)		Piezo Channel
T2623	PD98059	PD 98059	ERK , Aryl Hydrocarbon Receptor , MEK , Autophagy
	PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhibits autophagy.		ERK , Aryl Hydrocarbon Receptor , MEK , Autophagy
T7661	SD-169	SD 169	p38 MAPK
	SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.		p38 MAPK
T1847	Necrostatin-1	Nec-1,Necrostatin 1	Indoleamine 2,3-Dioxygenase (IDO) , Ferroptosis , Autophagy , RIP kinase
	Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin-1 also inhibits IDO.
T5194	SPHINX31		Serine/threonin kinase
	SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50: 5.9 nM).		Serine/threonin kinase
T4074	GSK-872	GSK872,GSK'872,GSK2399872A	RIP kinase
	GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM).		RIP kinase
T22436	Takeda-6d		VEGFR
	Takeda-6d, a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor, inhibits B-RAF and VEGFR2 with IC50 of 7.0nM and 2.2nM.		VEGFR
T6971	Ro 5126766	CH5126766,Avutometinib,VS-6766,RO5126766	Raf , MEK
	RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.		Raf , MEK
T1144L	Lidocaine Hydrochloride hydrate		EGFR , Sodium Channel
	Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.		EGFR , Sodium Channel
T2036	6-OAU	GTPL5846	GPR
	6-OAU (GTPL5846)(GTPL5846; 6-n-octylaminouracil) is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay.		GPR
T9079	Apostatin-1	Apt-1	Others
	Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.		Others
T2171	SEW2871	SEW2871	S1P Receptor , LPL Receptor
	SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, an...		S1P Receptor , LPL Receptor
T1606	Fasudil	HA-1077,AT877	ROCK , Serine/threonin kinase , Calcium Channel , PKA , PKC , Autophagy
	Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T5401	GSK2983559 active metabolite	GSK2983559,RIPK2 inhibitor 1,RIPK2-IN-1	RIP kinase
	GSK2983559 active metabolite (RIPK2-IN-1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.		RIP kinase
T0468	Lidocaine	Lignocaine,Alphacaine,Xylocaine	Apoptosis , ERK , NF-κB , MEK , Sodium Channel , Histamine Receptor
	Lidocaine (Alphacaine) is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellular adhesion molecule-1 (ICAM-1), pro-inflammat...
T9095	Necrostatin-34	2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4	RIP kinase
	Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.		RIP kinase
T7504	Necrostatin 2 racemate	Necrostatin-2 racemate	RIP kinase
	Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1.		RIP kinase

Compounds

CaMKII-IN-1

T14860

Synonym:

Target: CaMK, Autophagy

STO-609

T3546

Synonym: STO 609

Target: CaMK, AMPK, Autophagy

KN-93

T2697

Synonym:

Target: CaMK, Autophagy

A-484954

TQ0137

Synonym: A 484954

Target: CaMK, Parasite, Autophagy

Autocamtide-2-related inhibitory peptide

TP2310

Synonym:

Target: CaMK, Autophagy

NH125

T6605

Synonym:

Target: CaMK, Virus Protease, PKA, Antibacterial, PKC, Autophagy, Antifungal

A-3 hydrochloride

T14069

Synonym:

Target: CaMK, Casein Kinase, PKA, PKC

KN-62

T2694

Synonym:

Target: CaMK, P2X Receptor, Autophagy

Calmidazolium chloride

T10667

Synonym: R 24571

Target: CaMK, Autophagy

Trifluoperazine

T8389

Synonym: trifluoroperazine

Target: CaMK, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, P-gp, Autophagy

Synonym: GSK963 (Racemate)

Synonym: SRPK inhibitor

Target: Virus Protease, Serine/threonin kinase

Target: ERK, BMI-1, Epigenetic Reader Domain

Target: Others, RIP kinase

LM22B-10

T4496

Synonym: LM22B10

Target: ERK, Trk receptor, Akt

Trifluoperazine dihydrochloride

T1222

Synonym: Trifluoperazine 2HCl,SKF5019,Urinox

Target: CaMK, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, P-gp, Autophagy

PK68

T12493

Synonym:

Target: Others, RIP kinase

lavendustin C

T4185

Synonym: HDBA,NSC 666251

Target: CaMK, EGFR, Tyrosinase, Src

Yoda 1

T7506

Synonym:

Target: Piezo Channel

PD98059

T2623

Synonym: PD 98059

Target: ERK, Aryl Hydrocarbon Receptor, MEK, Autophagy

Synonym: Nec-1,Necrostatin 1

Target: Indoleamine 2,3-Dioxygenase (IDO), Ferroptosis, Autophagy, RIP kinase

SPHINX31

T5194

Synonym:

Target: Serine/threonin kinase

GSK-872

T4074

Synonym: GSK872,GSK'872,GSK2399872A

Synonym: CH5126766,Avutometinib,VS-6766,RO5126766

Target: Raf, MEK

Lidocaine Hydrochloride hydrate

T1144L

Synonym:

Target: EGFR, Sodium Channel

Target: S1P Receptor, LPL Receptor

Fasudil

T1606

Synonym: HA-1077,AT877

Target: ROCK, Serine/threonin kinase, Calcium Channel, PKA, PKC, Autophagy

GSK2983559 active metabolite

T5401

Synonym: GSK2983559,RIPK2 inhibitor 1,RIPK2-IN-1

Target: RIP kinase

Lidocaine

T0468

Synonym: Lignocaine,Alphacaine,Xylocaine

Target: Apoptosis, ERK, NF-κB, MEK, Sodium Channel, Histamine Receptor

Necrostatin-34

T9095

Synonym: 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4

Target: RIP kinase

Necrostatin 2 racemate

T7504

Synonym: Necrostatin-2 racemate

Target: RIP kinase

カタログ番号	製品名	別名	ターゲット
T3844	Deltonin		ERK , Others , Akt , Endogenous Metabolite
	Deltonin has an inhibition of ERK1/2 and AKT activation. Deltonin shows cytotoxicity against human HepG2 cells (IC50: 7.66 μM), mouse C26 cells (IC50: 1.22 μM), and human MDA-MB-231 cells (IC50: 1.58 μM).		ERK , Others , Akt , Endogenous Metabolite
T6S0619	Pachymic acid	3-O-Acetyltumulosic acid	ERK , Akt
	Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways.		ERK , Akt
TMS2181	Trans-Zeatin	(E)-Zeatin	ERK , MEK , Endogenous Metabolite
	trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing.		ERK , MEK , Endogenous Metabolite
T13265	Urolithin B		ERK , NF-κB , Akt , Endogenous Metabolite , JNK , AMPK
	Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical fruits, and medicinal herbs. Urolithin B inhibits NF-κB activit...		ERK , NF-κB , Akt , Endogenous Metabolite , JNK , AMPK
T3001	Honokiol	NSC 293100	ERK , HCV Protease , MEK , Akt , Autophagy
	Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.		ERK , HCV Protease , MEK , Akt , Autophagy
T5S0761	Nitidine chloride		Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite
	1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id...
T4291	(+)-Isocorydine hydrochloride	Isocorydine HCl	Serine/threonin kinase , Tyrosinase
	(+)-Isocorydine hydrochloride (Isocorydine HCl) is a eukaryote protein kinases Inhibitor.		Serine/threonin kinase , Tyrosinase
T3S2390	Caftaric acid	trans-Caftaric acid	Others
	Caftaric acid (trans-Caftaric acid) is a natural product with antioxidant and anti-inflammatory properties, antimutagenicity, and an inhibitor of protein-protein interactions mediated by Src family kinases.		Others
T3892	Isoacteoside	Isoverbascoside	NF-κB
	Isoacteoside has the anti-inflammatory effect, mediated by action on caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular signal-regulated protein kinase) and nuclear factor-kappa B p...		NF-κB
TN1440	Beta-Hydroxyisovalerylshikonin		EGFR , Tyrosine Kinases , Prostaglandin Receptor , Src , AMPK , Fatty Acid Synthase
	Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor cell lines. Beta-Hydroxyisovalerylshikonin significantly de...
T0610	Piceatannol	trans-Piceatannol,Astringenin	Apoptosis , Serine/threonin kinase , PKA , Syk , PKC , Autophagy
	Piceatannol (Astringenin) is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is...
TN1448	(-)-Bornyl acetate	L-(-)-Bornyl acetate,Bornyl acetate	p38 MAPK , NF-κB , JNK , Antifungal
	(-)-Bornyl acetate (L-(-)-Bornyl acetate) is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate isolates from hyssop oil and possesses antifungal activity. (-)-Bornyl acetate shows highly active whitening...		p38 MAPK , NF-κB , JNK , Antifungal
T6S1597	Mulberroside A		TNF , Tyrosinase , Interleukin
	1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosylation of Mulberroside A resulted in enhanced inhibition of...		TNF , Tyrosinase , Interleukin
T6S1684	8-Gingerol		Antioxidant , Antibacterial , TRP/TRPV Channel
	1. 8-Gingerol has antioxidant activity. 2. 8-Gingerol has antimycobacterial activity. 3. 8-Gingerol could be used as an effective skin-whitening agent. 4. 8-Gingerol shows antipyretic and anti-inflammation characteristic...		Antioxidant , Antibacterial , TRP/TRPV Channel
T3S0737	Flavokawain A	Flavokavain A	Apoptosis , p38 MAPK
	NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significant...		Apoptosis , p38 MAPK
TN3042	4-Hydroxycinnamamide		ATPase , EGFR , Potassium Channel , p38 MAPK , Calcium Channel , Sodium Channel , AMPK
	4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
T15637	K-252b		PKC
	K-252b, an indolocarbazole derived from the actinomycete Nocardiopsis, functions as a protein kinase C (PKC) inhibitor. It is effective in inhibiting extracellular kinases in cultured cells due to its inability to freely...		PKC
TN2775	2-Methoxystypandrone		MMP , BCL , IκB/IKK , GSK-3 , TNF , NOS , NF-κB , Wnt/beta-catenin , COX , JAK , STAT
	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflammation and oxidative stress for preservation of BBB integrit...

天然物製品

Deltonin

T3844

Synonym:

Target: ERK, Others, Akt, Endogenous Metabolite

Pachymic acid

T6S0619

Synonym: 3-O-Acetyltumulosic acid

Target: ERK, MEK, Endogenous Metabolite

Urolithin B

T13265

Synonym:

Target: ERK, NF-κB, Akt, Endogenous Metabolite, JNK, AMPK

Honokiol

T3001

Synonym: NSC 293100

Target: ERK, HCV Protease, MEK, Akt, Autophagy

Nitidine chloride

T5S0761

Synonym:

Target: Apoptosis, ERK, FAK, p38 MAPK, NF-κB, Topoisomerase, STAT, Parasite

(+)-Isocorydine hydrochloride

T4291

Synonym: Isocorydine HCl

Target: Serine/threonin kinase, Tyrosinase

Caftaric acid

T3S2390

Synonym: trans-Caftaric acid

Target: Others

Isoacteoside

T3892

Synonym: Isoverbascoside

Target: NF-κB

Beta-Hydroxyisovalerylshikonin

TN1440

Synonym:

Target: EGFR, Tyrosine Kinases, Prostaglandin Receptor, Src, AMPK, Fatty Acid Synthase

Piceatannol

T0610

Synonym: trans-Piceatannol,Astringenin

Target: Apoptosis, Serine/threonin kinase, PKA, Syk, PKC, Autophagy

(-)-Bornyl acetate

TN1448

Synonym: L-(-)-Bornyl acetate,Bornyl acetate

Target: p38 MAPK, NF-κB, JNK, Antifungal

Mulberroside A

T6S1597

Synonym:

Target: TNF, Tyrosinase, Interleukin

8-Gingerol

T6S1684

Synonym:

Target: Antioxidant, Antibacterial, TRP/TRPV Channel

Flavokawain A

T3S0737

Synonym: Flavokavain A

Target: Apoptosis, p38 MAPK

4-Hydroxycinnamamide

TN3042

Synonym:

Target: ATPase, EGFR, Potassium Channel, p38 MAPK, Calcium Channel, Sodium Channel, AMPK

Target: MMP, BCL, IκB/IKK, GSK-3, TNF, NOS, NF-κB, Wnt/beta-catenin, COX, JAK, STAT

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-02647	IFNAR1 Protein, Human, Recombinant (His)	Human	HEK293
	Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus prote...
TMPY-02953	TEM8/ANTXR1 Protein, Human, Recombinant (hFc)	Human	HEK293
	ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are ser...
TMPY-04384	Src Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C...
TMPY-04376	PLK1 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Serine / threonine-protein kinase PLK1 / PLK-1, also known as polo-like kinase 1 (PLK-1) or serine / threonine-protein kinase 13 (STPK13), Polo-like kinases (PLKs), is a family of four serine / threonine protein kinases ...
TMPJ-00113	CD79B Protein, Human, Recombinant (hFc)	Human	Human Cells
	CD79B is a single-pass type I membrane protein. CD79B contains one Ig-like V-type domain and one ITAM domain. CD79B is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the...
TMPY-05338	IL-10R alpha/IL-10RA Protein, Human, Recombinant (His)	Human	HEK293
	IL10RA (Interleukin 10 Receptor Subunit Alpha, also known as CD210) is a Protein Coding gene. The protein encoded by this gene is a receptor for interleukin 10. Two transcript variants, one protein-coding, and the other,...
TMPY-05496	IL-10R alpha/IL-10RA Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	IL10RA (Interleukin 10 Receptor Subunit Alpha, also known as CD210) is a Protein Coding gene. The protein encoded by this gene is a receptor for interleukin 10. Two transcript variants, one protein-coding, and the other,...
TMPY-05308	CD45 Protein, Human, Recombinant (aa 1-529, His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05748	CD45 Protein, Human, Recombinant (aa 26-577, His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-01289	DDR1 Protein, Human, Recombinant (His)	Human	HEK293
	Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracell...
TMPY-01168	ALK-1 Protein, Human, Recombinant (His)	Human	HEK293
	Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. ...
TMPY-04572	MKK4 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is...
TMPJ-00662	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)	Human	E. coli
	CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL i...
TMPY-00246	HER3/ERBB3 Protein, Rhesus, Recombinant	Rhesus	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-01389	HER3/ERBB3 Protein, Human, Recombinant (His)	Human	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-04125	PTP1B Protein, Human, Recombinant (His)	Human	E. coli
	PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly c...
TMPY-02477	HER3/ERBB3 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-02365	HER3/ERBB3 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-00399	HER3/ERBB3 Protein, Human, Recombinant	Human	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPJ-00166	SCF Protein, Mouse, Recombinant	Mouse	E. coli
	Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gameto...
TMPY-05779	Ephrin A1/EFNA1 Protein, Human, Recombinant (hFc)	Human	HEK293
	EPH-related receptor tyrosine kinase ligand 1 (abbreviated as Ephrin-A1) also known as ligand of eph-related kinase 1 or EFNA1, is a member of the ephrin (EPH) family. The Eph family receptor interacting proteins (ephrin...
TMPY-01936	VEGFR3/FLT4 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belo...
TMPY-03024	HER3/ERBB3 Protein, Rat, Recombinant (His)	Rat	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-04956	HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-01478	HSP90 alpha Protein, Human, Recombinant	Human	E. coli
	Heat shock protein 90 (90 kDa heat-shock protein, HSP90) is a molecular chaperone involved in the trafficking of proteins in the cell. It is a remarkably versatile protein involved in the stress response and normal homoe...
TMPY-00949	VEGFR3/FLT4 Protein, Human, Recombinant (His)	Human	HEK293
	Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belo...
TMPY-03484	TCPTP Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	Tyrosine-protein phosphatase non-receptor type 2, also known as T-cell protein-tyrosine phosphatase, PTPN2 and PTPT, is a cytoplasm protein that belongs to the protein-tyrosine phosphatase family and Non-receptor class 1...
TMPY-05588	EphA2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Eph receptor A2 (Ephrin type-A receptor 2 or EphA2) is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptors' corresponding family of ligands are the ephrins anchored to cell ...
TMPY-04632	IL-15 Protein, Human, Recombinant	Human	E. coli
	The protein encoded by the IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common h...
TMPJ-00850	ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)	Mouse	Human Cells
	ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes....
TMPJ-00412	VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)	Human	Human Cells
	Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 ...
TMPY-04750	CSNK2A2 Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	Casein kinase II subunit alpha', also known as CSNK2A2 and CK2A2, is a member of the protein kinase superfamily, Ser/Thr protein kinase family and CK2 subfamily. Casein kinases are operationally defined by their prefer...
TMPY-01608	Decorin Protein, Human, Recombinant (His)	Human	HEK293
	Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core p...
TMPY-04799	IFNAR2 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	Interferon-alpha/beta receptor beta chain (IFNAR2) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protei...
TMPY-01703	TREM-2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPY-00432	TREM-2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPY-01148	TREM-2 Protein, Human, Recombinant (His)	Human	HEK293
	Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPY-02900	IL-17A Protein, Mouse, Recombinant	Mouse	E. coli
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-02886	IL-17A Protein, Human, Recombinant	Human	E. coli
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-01601	AXL Protein, Human, Recombinant (His)	Human	HEK293
	Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multip...
TMPY-04396	C-ABL/ABL1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy...
TMPY-04566	CAMKV Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	CaM kinase-like vesicle-associated protein, also known as CAMKV, is a peripheral membrane protein and Cytoplasmic vesicle membrane protein which belongs to theprotein kinase superfamily and CAMK Ser/Thr protein kinase...
TMPY-04415	CAMKI Protein, Human, Recombinant	Human	E. coli
	Calcium/calmodulin-dependent protein kinase orCaM kinases are serine/threonine-specific protein kinasesthat are primarily regulated by the Calcium/calmodulin complex. These kinases show a memory effect on activation. ...
TMPH-03458	STE11 Protein, S. cerevisiae, Recombinant	Saccharomyces cerevisiae	E. coli
	Serine/threonine protein kinase required for cell-type-specific transcription and signal transduction in yeast. It is thought that it phosphorylates the STE7 protein kinase which itself, phosphorylates the FUS3 and or KS...
TMPY-04407	LOK Protein, Human, Recombinant (His)	Human	E. coli
	Serine / threonine-protein kinase 1, also known as Lymphocyte-oriented kinase, STK1 and LOK, belongs to the protein kinase superfamily, STE Ser / Thr protein kinase family and STE2 subfamily. Protein kinases constitute a...
TMPY-04411	YES1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Proto-oncogene tyrosine-protein kinase Yes, also known as Proto-oncogene c-Yes, p61-Yes and YES1, is a cytoplasm protein that belongs to the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. YES1 /...
TMPY-04756	MEK1 Protein, Mouse, Recombinant	Mouse	Baculovirus-Insect Cells
	MEK1, also known as MAP2K1 and MKK1, is a member of the dual-specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kin...
TMPY-04569	MEK1 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	MEK1, also known as MAP2K1 and MKK1, is a member of the dual-specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kin...
TMPY-04378	MAPKAPK3 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	The MAPKAP kinases are a group of MAP kinase substrates that are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases ...
TMPY-04381	CAMK1D Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	Calcium/calmodulin-dependent protein kinase orCaM kinases are serine/threonine-specific protein kinasesthat are primarily regulated by the Calcium/calmodulin complex. These kinases show a memory effect on activation. ...
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IFNAR1 Protein, Human, Recombinant (His)

TMPY-02647

Species: Human

Expression System: HEK293

TEM8/ANTXR1 Protein, Human, Recombinant (hFc)

TMPY-02953

Species: Human

Expression System: HEK293

Src Protein, Human, Recombinant (His & GST)

TMPY-04384

Species: Human

Expression System: Baculovirus-Insect Cells

PLK1 Protein, Human, Recombinant (His)

TMPY-04376

Species: Human

Expression System: Baculovirus-Insect Cells

CD79B Protein, Human, Recombinant (hFc)

TMPJ-00113

Species: Human

Expression System: Human Cells

IL-10R alpha/IL-10RA Protein, Human, Recombinant (His)

TMPY-05338

Species: Human

Expression System: HEK293

IL-10R alpha/IL-10RA Protein, Mouse, Recombinant (hFc)

TMPY-05496

Species: Mouse

Expression System: HEK293

CD45 Protein, Human, Recombinant (aa 1-529, His)

TMPY-05308

Species: Human

Expression System: HEK293

CD45 Protein, Human, Recombinant (aa 26-577, His)

TMPY-05748

Species: Human

Expression System: HEK293

DDR1 Protein, Human, Recombinant (His)

TMPY-01289

Species: Human

Expression System: HEK293

ALK-1 Protein, Human, Recombinant (His)

TMPY-01168

Species: Human

Expression System: HEK293

MKK4 Protein, Mouse, Recombinant (His & GST)

TMPY-04572

Species: Mouse

Expression System: Baculovirus-Insect Cells

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)

TMPJ-00662

Species: Human

Expression System: E. coli

HER3/ERBB3 Protein, Rhesus, Recombinant

TMPY-00246

Species: Rhesus

Expression System: HEK293

HER3/ERBB3 Protein, Human, Recombinant (His)

TMPY-01389

Species: Human

Expression System: HEK293

PTP1B Protein, Human, Recombinant (His)

TMPY-04125

Species: Human

Expression System: E. coli

HER3/ERBB3 Protein, Rhesus, Recombinant (His)

TMPY-02477

Species: Rhesus

Expression System: HEK293

HER3/ERBB3 Protein, Mouse, Recombinant (His)

TMPY-02365

Species: Mouse

Expression System: HEK293

HER3/ERBB3 Protein, Human, Recombinant

TMPY-00399

Species: Human

Expression System: HEK293

SCF Protein, Mouse, Recombinant

TMPJ-00166

Species: Mouse

Expression System: E. coli

Ephrin A1/EFNA1 Protein, Human, Recombinant (hFc)

TMPY-05779

Species: Human

Expression System: HEK293

VEGFR3/FLT4 Protein, Mouse, Recombinant (His)

TMPY-01936

Species: Mouse

Expression System: HEK293

HER3/ERBB3 Protein, Rat, Recombinant (His)

TMPY-03024

Species: Rat

Expression System: HEK293

HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated

TMPY-04956

Species: Human

Expression System: HEK293

HSP90 alpha Protein, Human, Recombinant

TMPY-01478

Species: Human

Expression System: E. coli

VEGFR3/FLT4 Protein, Human, Recombinant (His)

TMPY-00949

Species: Human

Expression System: HEK293

TCPTP Protein, Human, Recombinant

TMPY-03484

Species: Human

Expression System: Baculovirus-Insect Cells

EphA2 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPY-05588

Species: Human

Expression System: HEK293

IL-15 Protein, Human, Recombinant

TMPY-04632

Species: Human

Expression System: E. coli

ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)

TMPJ-00850

Species: Mouse

Expression System: Human Cells

VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)

TMPJ-00412

Species: Human

Expression System: Human Cells

CSNK2A2 Protein, Human, Recombinant

TMPY-04750

Species: Human

Expression System: Baculovirus-Insect Cells

Decorin Protein, Human, Recombinant (His)

TMPY-01608

Species: Human

Expression System: HEK293

IFNAR2 Protein, Human, Recombinant (His), Biotinylated

TMPY-04799

Species: Human

Expression System: HEK293

TREM-2 Protein, Mouse, Recombinant (His)

TMPY-01703

Species: Mouse

Expression System: HEK293

TREM-2 Protein, Mouse, Recombinant (hFc)

TMPY-00432

Species: Mouse

Expression System: HEK293

TREM-2 Protein, Human, Recombinant (His)

TMPY-01148

Species: Human

Expression System: HEK293

IL-17A Protein, Mouse, Recombinant

TMPY-02900

Species: Mouse

Expression System: E. coli

IL-17A Protein, Human, Recombinant

TMPY-02886

Species: Human

Expression System: E. coli

AXL Protein, Human, Recombinant (His)

TMPY-01601

Species: Human

Expression System: HEK293

C-ABL/ABL1 Protein, Human, Recombinant (GST)

TMPY-04396

Species: Human

Expression System: Baculovirus-Insect Cells

CAMKV Protein, Human, Recombinant (His & GST)

TMPY-04566

Species: Human

Expression System: Baculovirus-Insect Cells

CAMKI Protein, Human, Recombinant

TMPY-04415

Species: Human

Expression System: E. coli

STE11 Protein, S. cerevisiae, Recombinant

TMPH-03458

Species: Saccharomyces cerevisiae

Expression System: E. coli

LOK Protein, Human, Recombinant (His)

TMPY-04407

Species: Human

Expression System: E. coli

YES1 Protein, Human, Recombinant (His & GST)

TMPY-04411

Species: Human

Expression System: Baculovirus-Insect Cells

MEK1 Protein, Mouse, Recombinant

TMPY-04756

Species: Mouse

Expression System: Baculovirus-Insect Cells

MEK1 Protein, Mouse, Recombinant (His & GST)

TMPY-04569

Species: Mouse

Expression System: Baculovirus-Insect Cells

MAPKAPK3 Protein, Human, Recombinant (GST)

TMPY-04378

Species: Human

Expression System: Baculovirus-Insect Cells

CAMK1D Protein, Human, Recombinant (GST)

TMPY-04381

Species: Human

Expression System: Baculovirus-Insect Cells

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カタログ番号	製品名
L1610	FDA-Approved Kinase Inhibitor Library	263 compounds
	A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
L1400	MAPK Inhibitor Library	365 compounds
	A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;
L1600	Kinase Inhibitor Library	2700 compounds
	A unique collection of 2700 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;
L2200	Tyrosine Kinase Inhibitor Library	1016 compounds
	A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases;
L9410	Covalent Inhibitor Library	1920 compounds
	A unique collection of 1920 covalent Inhibitors and other molecules with common warheads like chloroacetyl，2-Chloropropionyl，Acryloyl，sulfonyl fluoride, alkyne，acrylamide, ketocarbonyl，disulfide bond, etc.

ライブラリー

FDA-Approved Kinase Inhibitor Library

L1610

Compounds: 263

MAPK Inhibitor Library

L1400

Compounds: 365

Kinase Inhibitor Library

L1600

Compounds: 2700

Tyrosine Kinase Inhibitor Library

L2200

Compounds: 1016

Covalent Inhibitor Library

L9410

Compounds: 1920